The Latest from Mayo Clinic Laboratories
As the global reference laboratory for Mayo Clinic, Mayo Clinic Laboratories will help you advance patient care, strengthen your practice, and broaden access to specialized testing. Through our partnerships with clinicians at Mayo Clinic and health care providers around the world, we are able to offer the most sophisticated test catalog in the world. It is because of these daily collaborations that our subspecialized laboratories continue to be a critical component to patient care at Mayo Clinic.
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Genome-wide methylation array analysisMayo Clinic Laboratories’ first-in-class genome-wide methylation array analysis (Mayo ID: MTNON) is a unique assay that provides the DNA methylation profile and MGMT promoter methylation status of CNS tumors through the use of a leading-edge testing platform (the Illumina Infinium MethylationEPIC v2.0) combined with the National Cancer Institute (NCI)-developed, AI-powered CNS tumor classifier algorithm and a Mayo Clinic-developed nearest-neighbors assisted unsupervised analysis (NN method). |
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Phenotype-specific approach transcends traditional testing for neurological conditionsAutoimmune neurology testing has evolved beyond limited paraneoplastic evaluations to phenotype-specific panels that identify clinically relevant antibodies. The latest “Eye on Innovation” looks at how this phenotype-specific approach significantly improves diagnostic accuracy, reduces false positives, and guides faster, more personalized treatment for complex neurological diseases. |
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Whole transcriptome RNA sequencingMayo Clinic Laboratories’ new whole transcriptome RNA sequencing (wtRNA-seq) assay is a unique and comprehensive approach to molecular tumor profiling that provides unparalleled detection of gene fusions. Using next-generation sequencing (NGS), the wtRNA-seq test identifies fusions in 1,445 genes to refine diagnosis and tailor treatment selection for many types of soft tissue, bone, and central nervous system (CNS) tumors. Unlike most RNA sequencing assays that cover only a few hundred genes, the new wtRNA-seq assay offers much broader coverage and is validated for use with cytology samples. |
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Multiple sclerosis: Diagnostic criteria update and kappa free light chain testingNeurology physicians and testing experts at Mayo Clinic Laboratories, who are at the forefront of translating emerging science into meaningful, clinically supported diagnostics, recognized the value of kappa free light chain years ago and implemented a pioneering, first-in-class multiple sclerosis (MS) testing cascade that aligns with the newest updates to the McDonald Criteria. For patients, access to answers enabled by the Mayo Clinic Laboratories MS cascade translates into quicker diagnosis and faster access to treatments. |
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Leveraging the LaboratorySept. 23–24, 2026 | Rochester, Minnesota. This year’s event, Leveraging the Laboratory: Bold Thinking. Big Impact., focuses on how innovative approaches and strategic decision-making can drive meaningful results for health system laboratory outreach programs. Hear from health system executives, industry experts, and experienced outreach leaders as they share practical insights on optimizing operations, identifying growth opportunities, and navigating an evolving healthcare environment. Through real-world examples and actionable strategies, sessions will highlight how bold ideas can translate into measurable impact. |
Education Program
Classical Hematology Conference: Nonmalignant Hematology and Bleeding and Thrombotic Disorders
Oct. 22-24, 2026 | Atlantic Beach, Florida. This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will illustrate available diagnostic tools to help guide the diagnosis and treatment of rare disorders of classical hematology. Informational presentations will be supplemented with case presentations, followed by time for participants’ questions.
How to Order Testing
Many hospitals across the country have already established an account with Mayo Clinic Laboratories. Please click on the links below to register for an account or sign-in.
Registration for an account takes less than 10 minutes, and new accounts are typically processed and available in one business day. Once registered, sign in and locate the test in the Test Catalog and click the “Order This Test” button. Follow the prompts to provide billing and contact information. Print the test requisition form to ship with the specimen.
More from Mayo Clinic Laboratories
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