As the global reference laboratory for Mayo Clinic, Mayo Clinic Laboratories will help you advance patient care, strengthen your practice, and broaden access to specialized testing. Through our partnerships with clinicians at Mayo Clinic and health care providers around the world, we are able to offer the most sophisticated test catalog in the world. It is because of these daily collaborations that our subspecialized laboratories continue to be a critical component to patient care at Mayo Clinic.
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Genome-wide methylation array analysisMayo Clinic Laboratories’ first-in-class genome-wide methylation array analysis (Mayo ID: MTNON) is a unique assay that provides the DNA methylation profile and MGMT promoter methylation status of CNS tumors through the use of a leading-edge testing platform (the Illumina Infinium MethylationEPIC v2.0) combined with the National Cancer Institute (NCI)-developed, AI-powered CNS tumor classifier algorithm and a Mayo Clinic-developed nearest-neighbors assisted unsupervised analysis (NN method). |
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Phenotype-specific approach transcends traditional testing for neurological conditionsAutoimmune neurology testing has evolved beyond limited paraneoplastic evaluations to phenotype-specific panels that identify clinically relevant antibodies. The latest “Eye on Innovation” looks at how this phenotype-specific approach significantly improves diagnostic accuracy, reduces false positives, and guides faster, more personalized treatment for complex neurological diseases. |
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Whole transcriptome RNA sequencingMayo Clinic Laboratories’ new whole transcriptome RNA sequencing (wtRNA-seq) assay is a unique and comprehensive approach to molecular tumor profiling that provides unparalleled detection of gene fusions. Using next-generation sequencing (NGS), the wtRNA-seq test identifies fusions in 1,445 genes to refine diagnosis and tailor treatment selection for many types of soft tissue, bone, and central nervous system (CNS) tumors. Unlike most RNA sequencing assays that cover only a few hundred genes, the new wtRNA-seq assay offers much broader coverage and is validated for use with cytology samples. |
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Multiple sclerosis: Diagnostic criteria update and kappa free light chain testingNeurology physicians and testing experts at Mayo Clinic Laboratories, who are at the forefront of translating emerging science into meaningful, clinically supported diagnostics, recognized the value of kappa free light chain years ago and implemented a pioneering, first-in-class multiple sclerosis (MS) testing cascade that aligns with the newest updates to the McDonald Criteria. For patients, access to answers enabled by the Mayo Clinic Laboratories MS cascade translates into quicker diagnosis and faster access to treatments. |
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Autoimmune dysautonomia testingMayo Clinic Laboratories’ industry-leading autoimmune dysautonomia evaluation (Mayo ID: DYS2) includes both common markers, such alpha-3 ganglionic acetylcholine receptor autoantibody (alpha-3-AChR), and rare markers, such as AP3B2, which is exclusive to Mayo Clinic. The evaluation’s innovative live cell-based flow cytometry method improves sensitivity for alpha-3-AChR detection and eliminates the need for radioactive reagents, enhancing both accuracy and laboratory safety. |
Education Program
Metagenomic Sequencing: A Revolutionary Approach to Aid in the Diagnosis of Serious and Complex Infections
Learn how metagenomic sequencing of microbial cell-free DNA (mcfDNA) has emerged as a precision technique to quickly and accurately diagnose serious and complex infections — which is particularly important in immunocompromised patients. This webinar will provide participants with an overview of mcfDNA metagenomic sequencing assays, including plasma and bronchoalveolar lavage fluid (BALF) testing, offered in collaboration with Karius. Participants will also learn about clinical decision-making around test ordering, appropriate clinical indications, and how to interpret and apply results to support timely diagnosis and patient management.
How to Order Testing
Many hospitals across the country have already established an account with Mayo Clinic Laboratories. Please click on the links below to register for an account or sign-in.
Registration for an account takes less than 10 minutes, and new accounts are typically processed and available in one business day. Once registered, sign in and locate the test in the Test Catalog and click the “Order This Test” button. Follow the prompts to provide billing and contact information. Print the test requisition form to ship with the specimen.
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