Mayo Clinic Center for Biomedical Discovery announces 2020 Discovery Science Award recipients
The Mayo Clinic Center for Biomedical Discovery announces 2020 Discovery Science Award recipients. These awards fund teams working on innovative, cutting-edge discovery science with a focus on understanding biological processes that contribute to human disease.
“NKG7 — A New Cell-Intrinsic Factor Regulating Cytotoxic Lymphocyte Killing”
Principal investigator: Haidong Dong, M.D., Ph.D. (IMM ’01), Urology/Immunology
Principal investigator: Daniel Billadeau, Ph.D. (IMM ’99), Medical Oncology
Co-investigators: Roxana Dronca, M.D. (HEMO ’10, CTSA ’15), Medical Oncology (Florida); Yiyi Yan, M.D., Ph.D. (HEMO ’17), Medical Oncology; Jie Sun, Ph.D. (THDCC ’16), Pulmonary and Critical Care Medicine/Immunology; Xiaosheng Wu, M.D. (PD ’99), Research Services
“Neuronal Autoantigen Discovery in Progressive Multiple Sclerosis”
Principal investigator: Charles Howe, Ph.D. (N ’03), Neurology
Principal investigator: Marion Curtis, Ph.D. (IMM ’18), Immunology (Arizona)
Principal investigator: John R. Mills, Ph.D. (CLCH ’15, CMG ’17), Laboratory Medicine and Pathology
“Functional and Mechanistic Characterization of the Dleu2 lncRNA in Hematopoiesis”
Principal investigator: Wenqian Hu, Ph.D. (BMB ’15), Biochemistry and Molecular Biology
Co-investigator: Kay Medina, Ph.D. (IMM ’05), Immunology
“Targeting the DOCK7-Rac1/Cdc42 Axis for Cancer Therapy”
Principal investigator: Zhenkun Lou, Ph.D. (PHAR ’01, ONCL ’06), Medical Oncology
Principal investigator: Daniel Billadeau, Ph.D. (IMM ’99), Medical Oncology
Principal investigator: Saravut Weroha, M.D., Ph.D. (I ’10, CI ’11, HEMO ’13), Medical Oncology
“Probing the Structural and Functional Divergence of SPOP Mutations in Cancer”
Principal investigator: Georges Mer, Ph.D. (MBIO ’01), Biochemistry
Co-investigators: Haojie Huang, Ph.D. (LABM ’99), Biochemistry and Molecular Biology; Jun Zhang, M.D. (PATH ’05), Anatomic and Clinical Pathology; Dejie Wang, Ph.D. (BIOC ’16), Research Services
“Landscape of Infiltrating Single Myeloid Cells in Cholangiocarcinoma (CCA)”
Principal investigator: Sumera Rizvi, M.B.B.S. (GI ’16, HEPT ’17), Gastroenterology
Principal investigator: Haidong Dong, M.D., Ph.D. (IMM ’01), Urology/Immunology
Co-investigators: Rory Smoot, M.D. (MED ’05, S ’08, CI ’10, S ’12), Surgery; Chen Wang, Ph.D. (HSR ’11), Health Sciences Research/Obstetrics and Gynecology; Rondell Graham, M.B.B.S. (PATH ’13, MGP ’14, SGPA ’15, GPTH ’16), Laboratory Medicine and Pathology
“Nuclear Import Receptors (NIRs) as Modifiers of TDP-43 Pathology”
Principal investigator: Wilfried Rossoll, Ph.D. (NSCI '18), Molecular Neuroscience (Florida)
Principal investigator: Ke Zhang, Ph.D. (NSCI '19), Molecular Neuroscience (Florida)
Principal investigator: Yongjie Zhang, Ph.D. (NSCI ’08), Molecular Neuroscience (Florida)
“Mechanisms of Lipolytic Exacerbation of Heart Failure”
Principal investigator: Vijay Singh, M.B.B.S. (I ’05, GI ’08), Gastroenterology (Arizona)
Co-investigators: Clifford Folmes, Ph.D. (CV ’12), Cardiovascular Disease (Arizona); Marek Belohlavek, M.D., Ph.D. (CV ’93, PHYS ’93, BPHY ’96), Cardiovascular Disease (Arizona)
“Elucidating the Mechanisms that Underlie Age-Related Pulmonary Fibrosis Following Influenza Infection: Roles of CD38-positive Tissue-resident Memory T cells and Tissue NAD Metabolism”
Principal investigator: Jie Sun, Ph.D. (THDCC ’16), Pulmonary and Critical Care Medicine/Immunology
Co-investigators: Eduardo Chini, M.D., Ph.D. (NEPH ’95, ANES ’01), Anesthesiology; Robert Vassallo, M.D. (I ’98, THDC ’01), Pulmonary and Critical Care Medicine/Physiology and Biomedical Engineering
“Develop PKD Models in Adult Zebrafish for Autophagy-based Therapy”
Principal investigator: Xiaolei Xu, Ph.D. (BIOC ’03), Biochemistry and Molecular Biology
Co-investigators: Peter Harris, Ph.D. (NEPH ’99), Nephrology; Slobodan Macura, Ph.D. (BIOC ’90), Biochemistry
“Targeting Poly(ADP-ribose) Polymerase 1 in C9orf72-mediated Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)”
Principal investigator: Ke Zhang, Ph.D. (NSCI '19), Molecular Neuroscience (Florida)
Co-investigators: Yongjie Zhang, Ph.D. (NSCI ’08), Neuroscience (Florida); Tania Gendron, Ph.D. (NSCI ’09), Neuroscience (Florida)