Breast Cancer Genome Guided Therapy (BEAUTY) study team receives 2019 Mayo Clinic Team Science Award
The Mayo Clinic Research Committee announced that the members of the Breast Cancer Genome Guided Therapy (BEAUTY) study team received the 2019 Mayo Clinic Team Science Award.
Matthew Goetz, M.D. (HEMO '03), Division of Medical Oncology, Mayo Clinic
David Potter, M.D., Ph.D., University of Minnesota
"Overcoming Hormone Therapy Resistance in ER+HER2 - Breast Cancer by Inhibition of Epoxyeicosatrienoic Acid Driven Signaling"
Alvaro Moreno Aspitia, M.D. (HEMO '00), Division of Hematology and Medical Oncology, Mayo Clinic in Florida
Donald Northfelt, M.D. (HEMO '02), Division of Hematology and Medical Oncology, Mayo Clinic in Arizona
Richard Gray, M.D. (S '00), Department of Surgery, CEO, Mayo Clinic in Arizona
Jodi Carter, M.D., Ph.D. (SPGA '13, BST '14), Division of Anatomic Pathology, Mayo Clinic in Rochester
Ann Moyer, M.D., Ph.D. (MDPH ’10, MPET ’10, PATH ’15, MGP ’16), Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology (5th place in 2019)
Daniel Visscher, M.D. (PATH '01), Division of Anatomic Pathology, Mayo Clinic in Rochester
Krishna Kalari, Ph.D. (BIOS '13), Division of Biomedical Statistics and Informatics, Mayo Clinic in Rochester
Katie Hunt, M.D. (RBR '09), Department of Radiology, Mayo Clinic in Rochester
Amy Conners, M.D. (RD '08), Department of Radiology, Mayo Clinic in Rochester
Vera Suman, Ph.D. (MSEP '90), Division of Biomedical Statistics and Informatics, Mayo Clinic in Rochester
Led by Matthew Goetz, M.D., and Judy Boughey, M.D., the BEAUTY team has worked together since 2011. Funded by the Center for Individualized Medicine and the Cancer Center, BEAUTY was the first study at Mayo Clinic and among the first worldwide to integrate comprehensive next-generation sequencing and creation of patient-derived xenografts (PDX) in a prospective clinical trial.
The BEAUTY study enrolled women who were receiving preoperative chemotherapy for stage I-III breast cancer. Tumor and blood specimens and breast imaging were collected prior to, during and after completion of chemotherapy and again at time of recurrence. Tumor specimens underwent comprehensive sequencing and were used to generate PDX.
Since 2014 the team has published notable peer-reviewed manuscripts including five directly related to BEAUTY and 19 that were enabled by BEAUTY data and resources. BEAUTY collaborations have led or contributed to external grants including a Mayo Clinic-Koch Institute Cancer Solution Team Grant, a U54 grant (Mayo Clinic and University of Illinois at Urbana-Champaign), four R01 grant, the Mayo Clinic Breast Cancer SPORE, two Department of Defense grants and two K awards; and has generated two patents. BEAUTY research also has provided the rationale and led to the novel design of four clinical trials testing new drugs against novel targets for the treatment of chemotherapy-resistant breast cancer.