Mayo Clinic Center for Biomedical Discovery announces pilot grants
Mayo Clinic Center for Biomedical Discovery announced recipients of pilot grants. The award provides focused, one-time funds for imaginative proof-of-principle studies or model development needed to lay the foundation for future mechanistic team science projects and grants. Selected projects fuel ideas that with continued support could flower into medical advances for patients who need cures and better treatments. The funded projects represent support for research in Rochester, Arizona and Florida across 17 specialties.
“Therapeutic Targeting of RORy+ Cells in Pancreatic Cancer”
Michael Barrett, Ph.D. (HSR '16), Division of Hematology and Medical Oncology, Mayo Clinic in Arizona
Martin Fernandez-Zapico, M.D. (GI ’02), Division of Medical Oncology, Department of Oncology, Mayo Clinic in Rochester
“New Tools to Study NKG7 in Human Cytotoxic Lymphocytes”
Haidong Dong, M.D., Ph.D. (IMM '01), Department of Urology, Mayo Clinic in Rochester
Daniel Billaeau, Ph.D. (IMM ’99), chair, Department of Immunology, Mayo Clinic in Rochester
“A Novel Method to Increase T-Cell Cytotoxicity to Tumors in Response to PD-1 Blockade”
Haidong Dong, M.D., Ph.D. (IMM ’01), Department of Urology, Mayo Clinic in Rochester
Roxana Dronca, M.D. (HEMO '10, CTSA '15), chair, Division of Hematology and Medical Oncology, Department of Internal Medicine, Mayo Clinic in Florida
Yiyi Yan, M.D., Ph.D. (HEMO ’17), Division of Medical Oncology, Department of Oncology, Mayo Clinic in Rochester
“The Essential Role of Primary Cilia in Heterotopic Ossification”
Haitao Wang, Ph.D. (PHYS '19), Department of Physiology and Biomedical Engineering, Mayo Clinic in Rochester
Jinghua Hu, Ph.D. (BIOC ’07), Department of Biochemistry and Molecular Biology, Mayo Clinic in Rochester
“Selectable Genetic Marker in Developing Breast Cancer”
Larry Pease, Ph.D. (IMM '84), Department of Immunology, Mayo Clinic in Rochester
Keith Robertson, Ph.D. (MPET ’16), Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic in Rochester
“Epigenetic Evolution of GATA2 Haploinsufficiency”
Mrinal Patnaik, M.B.B.S. (HEMO '11), Division of Hematology, Department of Medicine, Mayo Clinic in Rochester
Ryan Carr, M.D., Ph.D. (I ’18, HEMO ’21), Division of Hematology, Department of Medicine, Mayo Clinic in Rochester
Terra Lasho, Ph.D. (BMB ’14), Hematology Research, Mayo Clinic in Rochester
Moritz Binder, M.D. (I ’17), Division of Hematology, Department of Medicine, Mayo Clinic in Rochester
“Cellular Origins of Bone Marrow Adipose Tissue”
“Studies of Metabolic Regulation of Intestinal Macrophages in the Pathogenesis of IBD”
Wai Kee Eddie (W K Eddie) Ip, Ph.D. (IMM '19), Department of Immunology, Mayo Clinic in Rochester
“Establishing a Novel Mouse Model for in Vivo Studies on an Oncogenic Long Noncoding RNA”
Principal investigator: Wenqian Hu, Ph.D. (BMB ’15), Biochemistry and Molecular Biology
“In Vivo CRISPR Gene Activation to Treat Pulmonary Fibrosis”
Daniel Tschumperlin, Ph.D. (I '18), Department of Physiology and Biomedical Engineering, Mayo Clinic in Rochester
Christopher Evans, Ph.D. (PMR ’13), Department of Physical Medicine and Rehabilitation, Department of Medicine, Mayo Clinic in Rochester
Robert Vassallo, M.D. (I ’98, THD ’01), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic in Rochester
“Regulation of BH3-Only Bim Protein by PD-L1 Governs Chemotherapy-Induced Apoptosis in Colon Cancer”
Frank Sinicrope, M.D. (GI '02), Department of Medicine, Mayo Clinic in Rochester: clinician-investigator
Bo Qin, Ph.D. (ONLC ’15), Department of Oncology, Mayo Clinic in Rochester
“Patient-Specific, Induced Pluripotent Stem-Cell-Derived Cardiomyocyte Model of Mitochondrial Cardiomyopathy”
Tamas Kozicz, M.D., Ph.D. (SC '17), Department of Laboratory Medicine and Pathology, Mayo Clinic in Rochester
Timothy Nelson, M.D., Ph.D. (I ’08, CI ’10, CV ’10), Division of General Internal Medicine, Department of Medicine, Mayo Clinic in Rochester
Eva Morava-Kozicz, M.D., Ph.D. (SC ’17), Department of Laboratory Medicine and Pathology, Mayo Clinic in Rochester
“Augmenting YAP Activation to Accelerate Liver Regeneration”
Patrick Starlinger, M.D., Ph.D. (SGI ’20), Division of Hepatobiliary and Pancreas Surgery, Mayo Clinic in Rochester
Gregory Gores, M.D. (I ’83, GI ’86), Executive Dean for Research, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic in Rochester
“3-D Electronc Microscopic Analysis of Early Changes in Mitochondrial Morphology Using a Drosophila Model of Chemotherapy-Induced Peripheral Neuropathy”
Christopher Groen, Ph.D. (N '19), Department of Neurology, Mayo Clinic in Rochester
Anthony Windebank, M.D. (N ’81), Department of Neurology, Mayo Clinic in Rochester
“The Role of IL-33 in Airway Remodeling”
Alfred Doyle, Ph.D. (IMM '16), Research, Mayo Clinic in Arizona
Rodrigo Cartin-Ceba, M.D. (CCMI ’08, THDC ’10, CTSA ’13), Division of Pulmonary Medicine, Department of Internal Medicine, Mayo Clinic in Arizona
Elizabeth Jacobsen, Ph.D. (BIOC ’19), Division of Allergy, Asthma, and Clinical Immunology, Department of Internal Medicine, Mayo Clinic in Arizona
Benjamin Wright, M.D. (AIM ’19), Division of Allergy, Asthma, and Clinical Immunology, Department of Internal Medicine, Mayo Clinic in Arizona
Matthew Rank, M.D. (AIM ’08), chair, Division of Allergy, Asthma, and Clinical Immunology, Department of Internal Medicine, Mayo Clinic in Arizona
Hirohito Kita, M.D. (IMM ’91), Division of Allergy, Asthma, and Clinical Immunology, Department of Internal Medicine, Mayo Clinic in Arizona