Mayo Clinic Department of Laboratory Medicine & Pathology announces 2019 research awards

The Mayo Clinic in Rochester Department of Laboratory Medicine and Pathology announced 2019 research award recipients in three categories: Collaborative Awards, Research Awards, and Small Grants Program Awards.

Collaborative Awards

These awards support early development of faculty’s novel ideas that involve collaborations with colleagues in the Department of Laboratory Medicine and Pathology or other departments. These projects encourage alliances among scientists, laboratorians and pathologists that may lead to new tests and more broadly advance the science of the many disciplines in the department.

“Identification of Susceptibility and/or Protective Genes for Breast Cancer”

Collaborator: Celine Vachon, Ph.D. (HSR ’99), chair, Division of Epidemiology, Department of Health Sciences Research, professor of epidemiology

“Explore and Expand the Clinical Application of Next-Generation Sequencing for Cytomegalovirus in Transplant Recipients”

Collaborator: Raymund Razonable, M.D. (INFD ’02), Division of Infectious Diseases, Department of Medicine, professor of medicine

“Role of IRF5 in Development of Chronic Renal and Cardiovascular Injury”

Collaborator: Karl Nath, M.D. (NEPH ’96), Division of Nephrology and Hypertension, Department of Medicine

“Characterization of the Transcriptome of Castleman Disease: Identification of Novel Candidate Disease Mediators and Therapeutic Targets”

Collaborator: Angela Dispenzieri, M.D. (I ’94, HEMO ’98), Division of Hematology, Department of Medicine; Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology; Department of Molecular Medicine; professor of laboratory medicine and pathology and medicine; Serene M. and Frances C. Durling Professor

“Therapeutic Hypersensitization of Secretory Carcinomas to Entrectinib”

Collaborator: Jeffrey Janus, M.D. (ENT ’13, ENTH ’14), Department of Otolarynology – Head and Neck Surgery, assistant professor of otolaryngology

“Identifying Genetic- and Epigenetic-Risk Factors Predicting the Development of Therapy-Related Myeloid Neoplasms (t-MN) in Multiple Myeloma Patients Undergoing Treatment”

Collaborator: Mithun Shah, M.D., Ph.D. (HEMO ’17), Division of Hematology, Department of Medicine, assistant professor of medicine and oncology

“Biomarker Discovery for Predicting Pancreatic Cancer-Associated Venous Thromboembolism”

Collaborator: Akhilesh Pandey, M.D., Ph.D. (LABM & PATH ’18), Department of Laboratory Medicine and Pathology

“Antineuronal Nuclear Antibody 3 (ANNA3) Paraneoplastic Neurological Autoimmunity: Antigen-Specificity Discovery and Clinical Phenotype Characterization”

Collaborator: Eoin Flanagan, M.B., B.Ch. (I1 ’09, N ’12, NMS ’13, CTSC ’14, NAI ’14, NBN ’15, CTSA ’16), Department of Neurology, Department of Laboratory Medicine and Pathology, associate professor of neurology

“Predictive and Prognostic RNA Signatures of ER+ Breast Cancer in Benign Breast”

Collaborator: Kevin Halling, M.D., Ph.D. (PATH ’94, CMG ’95, MOGEN ’95), Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology; Department of Clinical Genomics, professor of laboratory medicine and pathology

“Genetic Basis of Tubulointerstitial Nephritis/Nephropathy”

Collaborator: Ann Moyer, M.D., Ph.D. (MDPH ’10, MPET ’10, PATH ’15, MGP ’16), Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, assistant professor of laboratory medicine and pathology and pharmacology

Research Awards

These awards support or supplement modest research projects and may include costs of minor equipment, statistical support and bridge funding.

“Targeting the Hypoxic Microenvironment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA ALCL)”

“TBX19 in Triple Negative Breast Cancer Development and Metastasis”

“Role of KLF11 in Development of Chronic Renal Injury”

“Determination of Urinary Extracellular Vesicle-Associated CD80 and CD163 as Biomarkers to Identify and Differentiate Primary Nephrotic Syndrome Specific Kidney Diseases”

“Idiopathic Pulmonary Fibrosis: Patient’s Adipose Tissue Mesenchymal Stem Cells and Immune Status; Preclinical Data Towards First-in-Man Clinical Protocol”

“Genomic Profiling of Cutaneous Melanocytic Lesions”

“Understanding Serum Biotin Clearance as a Means to Mitigate the Risk of Biotin Interference with Clinical Laboratory Tests: What is the Impact of Impaired Renal Function and Chronic Biotin Ingestion on Biotin Clearance?”

“Association between Specific Proteomic Signature and Tissue Tropism/Clinical Outcome in AL and ATTR Amyloidosis”

“Turning ‘Cold’ Tumors to ‘Hot’ Tumors with Epigenetic Therapy in Mesothelioma”

“Identifying Genetic and Epigenetic Features of Recurrence and Progression in Atypical Meningioma”

“Epigenetic Modulation of Notch Signaling in High-Grade Serous Ovarian Carcinoma”

“Differential Expression of Inflammatory Genes Aids in the Diagnosis of Antibody Mediated and Acute Rejection and Their Distinction from Morphologic Mimics in Lung Allografts”

“Preliminary Interrogation of Observed X Imbalance in UC-Neoplasm”

Small Grants Program

These awards provide funding for small clinical and translational research projects. The awards also support new tests and more broadly advance the science of the many disciplines in the department.

“Multi-Center Comparison of Body Fluid Chemistry Testing Methods”

“Development of an Animal Model for Fibrillary Glomerulopathy”

“SPORHE Cage Frames for Automated QoL Measurements of Tumor-Bearing Mice”

“Assessing Oxygenation and Gas Exchange during Airway Pressure Release Ventilation (APRV) in Patients with Acute Respiratory Distress Syndrome”

“Assessing the Prevalence and Magnitude of Biotin Interference with the Elecsys^® Troponin T Gen 5 STAT Assay in Patients Presenting to the Emergency Department”

“Clinical and Pathologic Characterization of B Cell Lymphomas with High Level MYC Amplification Identified by FISH”

“Single-Cell Transcriptomic Analysis of Staphylococcal Infection—A Pilot Study”

“Imaging Upgrade and Small Equipment Request for Current Oncology Research in the Shridhar Lab”

“Broad-Range Fungal rRNA Operon Sequencing and Analysis from Formalin-Fixed Paraffin-Embedded Tissue”

“Ovarian Tissue Cryopreservation to Preserve Fertility for Cancer Patients of Adolescent and Reproductive-Age Females”