High-intensity aerobic exercise can reverse aging processes in adults, Mayo research shows

A Mayo Clinic study has shown that high-intensity aerobic exercise can reverse some cellular aspects of aging.

Mayo researchers compared high-intensity interval training, resistance training and combined training. All training types improved lean body mass and insulin sensitivity, but only high-intensity and combined training improved aerobic capacity and mitochondrial function for skeletal muscle. Decline in mitochondrial content and function are common in older adults.

High-intensity intervals also improved muscle protein content that not only enhanced energetic functions but also caused muscle enlargement, especially in older adults. The researchers emphasized an important finding: Exercise training significantly enhanced the cellular machinery responsible for making new proteins. That contributes to protein synthesis, thus reversing a major adverse effect of aging. However, adding resistance training is important to achieve significant muscle strength.

“We encourage everyone to exercise regularly, but the take-home message for aging adults is that supervised high-intensity training is probably best because, both metabolically and at the molecular level, it confers the most benefits,” says K. Sreekumaran Nair, M.D., Ph.D. (ENDO ’97), Mayo Clinic Department of Endocrinology, the senior researcher on the study. He says the high-intensity training reversed some manifestations of aging in the body’s protein function. Dr. Nair cautioned that increasing muscle strength requires resistance training a couple of days a week.

The study’s goal was to find evidence that will help develop targeted therapies and exercise recommendations at various ages. Researchers tracked metabolic and molecular changes in a group of young and older adults over 12 weeks, gathering data 72 hours after individuals in randomized groups completed each type of exercise. General findings showed:

• Cardio respiratory health, muscle mass and insulin sensitivity improved with all training.
• Mitochondrial cellular function declined with age but improved with training.
• Increase in muscle strength occurred only modestly with high-intensity training but occurred with resistance training alone or when added to the aerobic training.
• Exercise improves skeletal muscle gene expression independent of age.
• Exercise substantially enhanced the ribosomal proteins responsible for synthesizing new proteins, which is mainly responsible for enhanced mitochondrial function.
• Training has little effect on skeletal muscle DNA energy transfer but promotes skeletal muscle protein expression with maximum effect in older adults.

The findings appear in Cell Metabolism.