Mayo Clinic Department of Laboratory Medicine & Pathology announces 2019 research awards

The Mayo Clinic in Rochester Department of Laboratory Medicine and Pathology announced 2019 research award recipients in three categories: Collaborative Awards, Research Awards, and Small Grants Program Awards.

Collaborative Awards

These awards support early development of faculty’s novel ideas that involve collaborations with colleagues in the Department of Laboratory Medicine and Pathology or other departments. These projects encourage alliances among scientists, laboratorians and pathologists that may lead to new tests and more broadly advance the science of the many disciplines in the department.

“Identification of Susceptibility and/or Protective Genes for Breast Cancer”

Fergus Couch, Ph.D. (PATH '97)
Division of Experimental Pathology and Laboratory Medicine
Department of Laboratory Medicine and Pathology
Department of Health Sciences Research
Department of Biochemistry and Molecular Biology
Professor of laboratory medicine and pathology

Collaborator: Celine Vachon, Ph.D. (HSR ’99), chair, Division of Epidemiology, Department of Health Sciences Research, professor of epidemiology

“Explore and Expand the Clinical Application of Next-Generation Sequencing for Cytomegalovirus in Transplant Recipients”

Matthew Binnicker, Ph.D. (CM '06)
Division of Clinical Microbiology
Department of Laboratory Medicine and Pathology
Associate professor of laboratory medicine and pathology

Collaborator: Raymund Razonable, M.D. (INFD ’02), Division of Infectious Diseases, Department of Medicine, professor of medicine

“Role of IRF5 in Development of Chronic Renal and Cardiovascular Injury”

Teacher of the Year - Basic Science
Joseph Grande, M.D., Ph.D. (PATH '89, LABM '91)
Division of Anatomic Pathology
Department of Laboratory Medicine and Pathology

Collaborator: Karl Nath, M.D. (NEPH ’96), Division of Nephrology and Hypertension, Department of Medicine

“Characterization of the Transcriptome of Castleman Disease: Identification of Novel Candidate Disease Mediators and Therapeutic Targets”

Pedro Horna, M.D. (HEMP '16)
Division of Hematopathology
Department of Laboratory Medicine and Pathology
Associate professor of laboratory medicine and pathology

Collaborator: Angela Dispenzieri, M.D. (I ’94, HEMO ’98), Division of Hematology, Department of Medicine; Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology; Department of Molecular Medicine; professor of laboratory medicine and pathology and medicine; Serene M. and Frances C. Durling Professor

“Therapeutic Hypersensitization of Secretory Carcinomas to Entrectinib”

Collaborator: Jeffrey Janus, M.D. (ENT ’13, ENTH ’14), Department of Otolarynology – Head and Neck Surgery, assistant professor of otolaryngology

“Identifying Genetic- and Epigenetic-Risk Factors Predicting the Development of Therapy-Related Myeloid Neoplasms (t-MN) in Multiple Myeloma Patients Undergoing Treatment”

Collaborator: Mithun Shah, M.D., Ph.D. (HEMO ’17), Division of Hematology, Department of Medicine, assistant professor of medicine and oncology

“Biomarker Discovery for Predicting Pancreatic Cancer-Associated Venous Thromboembolism”

Aneel Ashrani, M.D. (HEMO '06)
Division of Hematology
Department of Medicine
Assistant professor of laboratory medicine and pathology and medicine

Collaborator: Akhilesh Pandey, M.D., Ph.D. (LABM & PATH ’18), Department of Laboratory Medicine and Pathology

“Antineuronal Nuclear Antibody 3 (ANNA3) Paraneoplastic Neurological Autoimmunity: Antigen-Specificity Discovery and Clinical Phenotype Characterization”

Anastasia Zekeridou, M.D., Ph.D. (LABM '15, NAI '18), Division of Clinical Biochemistry and Immunology
"Investigations of CSF Cytokine Profiles as Diagnostic Biomarkers and Therapeutic Targets of Neurological Autoimmunity"

Collaborator: Eoin Flanagan, M.B., B.Ch. (I1 ’09, N ’12, NMS ’13, CTSC ’14, NAI ’14, NBN ’15, CTSA ’16), Department of Neurology, Department of Laboratory Medicine and Pathology, associate professor of neurology

“Predictive and Prognostic RNA Signatures of ER+ Breast Cancer in Benign Breast”

Jodi Carter, M.D., Ph.D. (SPGA '13, BST '14), Division of Anatomic Pathology, Mayo Clinic in Rochester

Collaborator: Kevin Halling, M.D., Ph.D. (PATH ’94, CMG ’95, MOGEN ’95), Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology; Department of Clinical Genomics, professor of laboratory medicine and pathology

“Genetic Basis of Tubulointerstitial Nephritis/Nephropathy”

Lynn Cornell, M.D. (PATH '07)
Division of Anatomic Pathology
Department of Laboratory Medicine and Pathology
Associate professor of laboratory medicine and pathology

Collaborator: Ann Moyer, M.D., Ph.D. (MDPH ’10, MPET ’10, PATH ’15, MGP ’16), Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, assistant professor of laboratory medicine and pathology and pharmacology

Research Awards

These awards support or supplement modest research projects and may include costs of minor equipment, statistical support and bridge funding.

“Targeting the Hypoxic Microenvironment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA ALCL)”

“TBX19 in Triple Negative Breast Cancer Development and Metastasis”

Fergus Couch, Ph.D. (PATH '97)
Division of Experimental Pathology and Laboratory Medicine
Department of Laboratory Medicine and Pathology
Department of Health Sciences Research
Department of Biochemistry and Molecular Biology
Professor of laboratory medicine and pathology

“Role of KLF11 in Development of Chronic Renal Injury”

Joseph Grande, M.D., Ph.D. (PATH '89, LABM '91)
Department of Laboratory Medicine and Pathology
Division of Nephrology and Hypertension
Department of Medicine
Professor of laboratory medicine and pathology

“Determination of Urinary Extracellular Vesicle-Associated CD80 and CD163 as Biomarkers to Identify and Differentiate Primary Nephrotic Syndrome Specific Kidney Diseases”

John Lieske, M.D. (NEPH '08)
Division of Nephrology and Hypertension
Department of Medicine
Department of Immunology
Department of Physiology and Biomedical Engineering
Professor of medicine

Marie Hogan, M.D., Ph.D. (I ’99, NEPH ’01, MBIO ’05), Division of Nephrology and Hypertension

“Idiopathic Pulmonary Fibrosis: Patient’s Adipose Tissue Mesenchymal Stem Cells and Immune Status; Preclinical Data Towards First-in-Man Clinical Protocol”

Allan Dietz, Ph.D. (ONCL '02)
Division of Transfusion Medicine
Department of Laboratory Medicine and Pathology
Department of Immunology
Associate professor of laboratory medicine and pathology
Instructor in biochemistry and molecular biology

“Genomic Profiling of Cutaneous Melanocytic Lesions”

Katherine Geiersbach, M.D. (LABM & PATH '16)
Division of Laboratory Genetics and Genomics
Department of Laboratory Medicine and Pathology
Department of Clinical Genomics
Assistant professor of laboratory medicine and pathology

“Understanding Serum Biotin Clearance as a Means to Mitigate the Risk of Biotin Interference with Clinical Laboratory Tests: What is the Impact of Impaired Renal Function and Chronic Biotin Ingestion on Biotin Clearance?”

Brooke Katzman, Ph.D. (CLCH '16)
Division of Clinical Core Laboratory Services
Department of Laboratory Medicine and Pathology
Instructor in laboratory medicine and pathology

“Association between Specific Proteomic Signature and Tissue Tropism/Clinical Outcome in AL and ATTR Amyloidosis”

Ellen McPhail, M.D. (I1 '93, PATH '97, SPGA '98, HEMP '99)
Division of Hematopathology
Department of Laboratory Medicine and Pathology
Associate professor of laboratory medicine and pathology

“Turning ‘Cold’ Tumors to ‘Hot’ Tumors with Epigenetic Therapy in Mesothelioma”

Julian Molina, M.D., Ph.D. (HEMO '04)
Division of Medical Oncology
Department of Oncology
Department of Laboratory Medicine and Pathology
Department of Molecular Medicine
Professor of oncology

Vijayalakshmi (Viji) Shridhar, Ph.D. (LABM 02)
Division of Experimental Pathology and Laboratory Medicine
Department of Laboratory Medicine and Pathology
Department of Obstetrics and Gynecology
Professor of laboratory medicine and pathology

“Identifying Genetic and Epigenetic Features of Recurrence and Progression in Atypical Meningioma”

Aditya Raghunathan, M.D. (LABM & PATH '15)
Division of Anatomic Pathology
Department of Laboratory Medicine and Pathology
Assistant professor of laboratory medicine and pathology

“Epigenetic Modulation of Notch Signaling in High-Grade Serous Ovarian Carcinoma”

Alexandre Gaspar Maia, Ph.D. (LABM & PATH '17)
Division of Experimental Pathology and Laboratory Medicine
Department of Laboratory Medicine and Pathology
Assistant professor of laboratory medicine and pathology

“Differential Expression of Inflammatory Genes Aids in the Diagnosis of Antibody Mediated and Acute Rejection and Their Distinction from Morphologic Mimics in Lung Allografts”

Anja Roden, M.D. (PATH '08, SGPA '09)
Division of Anatomic Pathology
Department of Laboratory Medicine and Pathology
Professor of laboratory medicine and pathology

“Preliminary Interrogation of Observed X Imbalance in UC-Neoplasm”

Thomas Smyrk, M.D.
Division of Anatomic Pathology
Department of Laboratory Medicine and Pathology
Professor of laboratory medicine and pathology

Small Grants Program

These awards provide funding for small clinical and translational research projects. The awards also support new tests and more broadly advance the science of the many disciplines in the department.

“Multi-Center Comparison of Body Fluid Chemistry Testing Methods”

“Development of an Animal Model for Fibrillary Glomerulopathy”

Joseph Grande, M.D., Ph.D. (PATH '89, LABM '91)
Department of Laboratory Medicine and Pathology
Division of Nephrology and Hypertension
Department of Medicine
Professor of laboratory medicine and pathology

“SPORHE Cage Frames for Automated QoL Measurements of Tumor-Bearing Mice”

Nagarajan (Raj) Kannan, Ph.D. (LABM & PATH '16)
Division of Experimental Pathology and Laboratory Medicine
Department of Laboratory Medicine and Pathology
Assistant professor of laboratory medicine and pathology

“Assessing Oxygenation and Gas Exchange during Airway Pressure Release Ventilation (APRV) in Patients with Acute Respiratory Distress Syndrome”

“Assessing the Prevalence and Magnitude of Biotin Interference with the Elecsys® Troponin T Gen 5 STAT Assay in Patients Presenting to the Emergency Department”

Brooke Katzman, Ph.D. (CLCH '16)
Division of Clinical Core Laboratory Services
Department of Laboratory Medicine and Pathology
Instructor in laboratory medicine and pathology

“Clinical and Pathologic Characterization of B Cell Lymphomas with High Level MYC Amplification Identified by FISH”

Rebecca L. King, M.D. (HEMP '12)
Division of Hematopathology
Department of Laboratory Medicine and Pathology
Assistant professor of laboratory medicine and pathology

“Single-Cell Transcriptomic Analysis of Staphylococcal Infection—A Pilot Study”

“Imaging Upgrade and Small Equipment Request for Current Oncology Research in the Shridhar Lab”

Vijayalakshmi (Viji) Shridhar, Ph.D. (LABM 02)
Division of Experimental Pathology and Laboratory Medicine
Department of Laboratory Medicine and Pathology
Department of Obstetrics and Gynecology
Professor of laboratory medicine and pathology

“Broad-Range Fungal rRNA Operon Sequencing and Analysis from Formalin-Fixed Paraffin-Embedded Tissue”

Nancy Wengenack, Ph.D. (BIOC '00, HEMO '00, CM '02), Division of Clinic Microbiology
"Rapid Molecular Detection of Drug Resistance Markers in Mycobacterium Tuberculosis Using Nanoprene Sequencing"

“Ovarian Tissue Cryopreservation to Preserve Fertility for Cancer Patients of Adolescent and Reproductive-Age Females”

Yulian Zhao, M.D., Ph.D. (LABM & PATH '17)
Division of Reproductive Endocrinology and Infertility
Department of Obstetrics and Gynecology
Department of Laboratory Medicine and Pathology
Professor of obstetrics and gynecology

 

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